Biomedical Research

AR-226-0183 - Study Plan: Perflurooctane Sulfonic Acid Induced HMG-CoA Reductase Inhibition in Pregnant Rats and Rat Pups

AR-226-0182 - Protocol for Study Nos. T-6295.23; ST-46: Exploratory In-Vitro Percutaneous Absorption Study of Theophylline, Salicylic Acid, Perfluorooctylsulfonate, and Ammonium Perfluorooctanoate in Skin Ethic Reconstituted Epidermis Model

AR-226-0180 - Protocol for Study No. T-7098.1: Pharmacokinetic Study of PFOS in Rats

AR-226-0173 - Pilot Teratology Study in Rats: T- 3551 Final Report, attached to memorandum to 3M (List of Section Attachments is first page of this file)

AR-226-0172 - Displacement of a Fluorescently Labeled Fatty Acid Analogue from Fatty Acid Carrier Proteins by Wyeth-14,643, Ammonium Perfluorooctanoate, Potassium Perfluorooctane Sulfonate & Other Known Peroxisome Proliferators: Abstract-Soc. of Tox. Annual Meeting

AR-226-0171 - Effect of Acute FC Administration on Catalase and acylCoA Oxidase Expression

AR-226-0170 - Effects of Selected Perfluoro-Compounds on Mitochondrial Beta-Oxidation

AR-226-0169 - Summary of the Effects of PFC's on Mitochondrial Bioenergetics in vitro

AR-226-0167 - The Effect of Perfluorinated Arylalkylsulfonamides on Bioenergetics of Rat Liver Mitochondria

AR-226-0166 - Effect of N-Alkyl Perfluorooctylsulfonamides on Mitochondrial Bioenergetics in vitro (Executive Summary and Attachment A: "Biochemical and Molecular Mechanistic Studies of N- Alkyl Perfluorosulfonamides" only)

AR-226-0164 - Perfluorosulfonamide Metabolism in Rat vs. Human Hepatocytes

AR-226-0158 - Final Report: Single-Dose Dermal Absorption/Toxicity Study of T- 6053 in Rabbits, with Protocol and in vivo Study HWI 6329-137

AR-226-0157 - Final Report: Single-Dose Intravenous Pharmacokinetic Study of T-6053 in Rabbits, with Protocol and in vivo Study No. AMDT- 010495.1

AR-226-0156 - 28 Day Percutaneous Absorption Study with FC-99 in Albino Rabbits

AR-226-0155 - 28 Day Percutaneous Absorption Study with FC-95 in Albino Rabbits

AR-226-0151 - Laboratory Report: Interim Report of Preliminary Data for 26 Week Capsule Toxicology Study with PFOS in Cynomolgus Monkeys

AR-226-0149 - Pathology Report (Ancillary Study): Electron Microscopic Evaluation of Liver in Cynomolgus Monkeys - 26-Week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; T-6295) in Cynomolgus Monkeys

AR-226-0147 - Dose-Setting Rationale for Six- Month Chronic Oral Study in Cynomolgus Monkeys

AR-226-0141 - Liver Slide Review (3M Memorandum relaying results of an independent histopathologic review of liver slides from the 104-Week Study listed as AR 226-0140)

AR-226-0138 - Ninety-Day Subacute Rhesus Monkey Toxicity Study, with Fluorad Fluorochemical Surfactant FC-95 (Aborted Study)