Comment from J B

As an academic scientist working on the cutting edge of childhood cancer research, I strongly urge against the adoption of this rule. The NIH has helped fund my work which directly contributes to our understanding of pediatric cancer and helps inform which therapeutics will be most effective for a given patient. The proposed modifications would directly harm my research as well as the larger research enterprise which makes the united states a global scientific leader. In particular, the following items are especially concerning: • §200.205 — Political appointee review of grants • §200.340 — Grant termination • §200.432 — Conference attendance pre-approval • §200.454 — Journal subscriptions (now unallowable) • §200.461 — Publication costs (now unallowable) • §200.300 — DEI and gender ideology prohibitions • §200.218 — Disparate-impact research banned • §200.220 — Foreign collaboration prohibition • §200.202 — Programs must align with administration priorities • §200.204 — Grant competitions can be exempted from public notice Each of these items will impact scientific research in the United States on both an individual and systemic level. My work, my lab, my university, and the scientific community as a whole will be damaged by the politicization of federal funding which is meant to support research which benefits everyone. In conclusion, I strongly urge the committee to refrain from adopting this provision.