Comment from Americans for Scientific Integrity
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Summary: Americans for Scientific Integrity is submitting a supplemental comment in support of their citizen petition requesting a precautionary allergic disease warning for pediatric acetaminophen products. They argue that new evidence—including biomarker data, mechanistic studies on lung injury, and large-scale epidemiological data—strengthens the link between early-life acetaminophen exposure and later respiratory or allergic diseases.
Americans for Scientific Integrity submits the attached supplemental comment in support of its citizen petition requesting a precautionary allergic disease warning for OTC pediatric acetaminophen products. The supplemental comment identifies four additional studies, numbered as References [23] through [26], that further support the requested warning. These studies add objective cord-blood biomarker evidence, new mechanistic evidence from the University of Colorado group showing acetaminophen-related injury and inflammatory signaling in the developing lung, large Global Asthma Network data linking paracetamol exposure with allergic rhinitis, and Mendelian randomization evidence supporting a potential causal relationship between paracetamol use and chronic lung disease risk. Taken together, these studies strengthen the petition’s central point: the association between early-life acetaminophen exposure and later respiratory or allergic disease is sufficiently consistent, biologically plausible, and clinically important to warrant basic caregiver risk communication and precautionary labeling.