Comment from Desiree B.

Thank you for the opportunity to comment on this topic. As someone who has a close family member affected by obesity, I&rsquo;ve seen firsthand how complex it is and how it can impact overall health and medical care.<br/><br/>BMI is a helpful starting point, but it doesn&rsquo;t capture the full picture. It doesn&rsquo;t account for differences in body composition, fat distribution, or metabolism, all of which can affect how medications work in the body. Using additional measures like body fat percentage, waist circumference, or other clinical markers could provide more accurate guidance.<br/><br/>It&rsquo;s also important to consider the type of drug, since some medications may behave differently depending on body fat or related health conditions like diabetes.<br/><br/>Overall, I think it&rsquo;s important to include more individuals with obesity in clinical trials and look beyond BMI so dosing recommendations are safer and more effective for real patients.