Comment from Day Alexander

Docket No. FDA-2018-N-3240 for “List of Bulk Drug Substances for Which There is a Clinical Need Under Section 503B of the Federal Food, Drug, and Cosmetic Act.” Too Long; Didn't Read summary: I've been using multiple different peptides since August 2025 and have suffered no serious side effects but gained immense benefit in the form of immense weight loss. I think Peptides are miracle drugs that may be a timely and desperately-needed solution to this nation's obesity crisis if we don't make the terrible mistake of gatekeeping them or the horrific travesty of banning then. I think the government should create a trust composed of certified labs that are guided to decrease the cost of peptides to as low as possible and that anyone should be able to order from these labs. Those who have already been testing peptides out on themselves should be able to continue to do so since they know what they are doing. And doctors should be able to order from these trusted labs to get the rest of the more cautious population to use these peptides to reverse the tide of obesity. My story: I'm a 38 year old male, been single pretty much my whole life. In 2025, I hit 350 pounds. I've struggled with my weight my whole life. A friend showed me a website where I could order research compounds such as |Semaglutide, Tirzepatide, Retratutide, Cagrilintide, and more. I ordered Tirzepatide and bacteriostatic water and then syringes from Amazon. On 08/03/2025 I ate a burger, fries and ice cream sundae and then I took my first injection of Tirzepatide. On 08/04/2025 I weighed 341.6 lbs. I water fasted (no food) from 8/4 through 8/6. On 8/7, I ate 1 peach, 4 hardboiled eggs and 6 radishes over the course of the day, and I wasn't even hungry when I ate them, and I was full after eating. In the following months, there were weeks where I fasted for 5 days, weeks where I ate every day, and I certainly never managed to do the only protein and vegetables diet I had intended to do. On 04/03/2026, I weighed 249.6 lbs. I had no side effects while on Tirzepatide. Once I used up my last dose of my most recent bottle of Tirzepatide, decided to try Cagrilintide and then Retratutide. Cagrilintide was a strong appetite suppressant at first but made me want to go to bed right after work and sleep until my next shift for a month, which I've read is expected, it got better after 4 weeks which was also predicted. Retratutide seemed to give me energy, and interestingly I could quickly become full eating very little on Retratutide the same as Tirzepatide, but it became very difficult to fast on Retratutide because every day I felt like I needed to eat some protein. But if I ate enough protein I would then be satiated for the day. 3 Nurri protein drinks (30g protein, 150 calories each drink) is usually enough to satisfy me for a day. I've hovered between 240 and 250 lbs for the past 2 months due to family and friends constantly wanting to eat and eating more than I needed to, and me struggling to fast which is when I saw the best weight loss, although I've noticed I seem to be able to lose weight if I could stick to just drinking 1-3 Nurri drinks a day. I'm planning to order more Tirzepatide and resume trying to lose another 70 or so pounds hopefully by 2027.