Comment submitted by People for the Ethical Treatment of Animals (PETA) Science Consortium International (PSCI)

Summary: Andreas Stucki, representing the PETA Science Consortium International, argues that the agency should exercise caution when using rat inhalation toxicity data to determine human health risks. He specifically notes that certain findings in rats, such as eosinophilic globules, may be age-related background findings rather than treatment-related effects, and advocates for the use of human-relevant in vitro and in silico methods.